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Formal (4+2) cycloaddition of azoalkenes with trifluoromethylimidoyl sulfoxonium ylides: synthesis of trifluoromethyl pyridazine derivatives.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Oct 17; Vol. 59 (83), pp. 12495-12498. Date of Electronic Publication: 2023 Oct 17. - Publication Year :
- 2023
-
Abstract
- CF <subscript>3</subscript> -substituted imidoyl sulfoxonium ylides (TFISYs) are extraordinarily versatile and powerful synthons for use in cyclization chemistry that affords diverse CF <subscript>3</subscript> -substituted N-heterocycles. We first reacted TFISYs as a two-atom synthon with readily available azoalkenes and then subjected the products to metal-free formal (4+2) cycloaddition chemistry. This protocol features mild conditions and broad substrate scope, is simple to operate, and provides highly functionalized trifluoromethylpyridazines that are widely found in bioactive molecules.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 59
- Issue :
- 83
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 37786379
- Full Text :
- https://doi.org/10.1039/d3cc03950a