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Challenges in developing personalized neoantigen cancer vaccines.
- Source :
-
Nature reviews. Immunology [Nat Rev Immunol] 2024 Mar; Vol. 24 (3), pp. 213-227. Date of Electronic Publication: 2023 Oct 02. - Publication Year :
- 2024
-
Abstract
- The recent success of cancer immunotherapies has highlighted the benefit of harnessing the immune system for cancer treatment. Vaccines have a long history of promoting immunity to pathogens and, consequently, vaccines targeting cancer neoantigens have been championed as a tool to direct and amplify immune responses against tumours while sparing healthy tissue. In recent years, extensive preclinical research and more than one hundred clinical trials have tested different strategies of neoantigen discovery and vaccine formulations. However, despite the enthusiasm for neoantigen vaccines, proof of unequivocal efficacy has remained beyond reach for the majority of clinical trials. In this Review, we focus on the key obstacles pertaining to vaccine design and tumour environment that remain to be overcome in order to unleash the true potential of neoantigen vaccines in cancer therapy.<br /> (© 2023. Springer Nature Limited.)
Details
- Language :
- English
- ISSN :
- 1474-1741
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nature reviews. Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 37783860
- Full Text :
- https://doi.org/10.1038/s41577-023-00937-y