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Ex vivo drug response profiling for response and outcome prediction in hematologic malignancies: the prospective non-interventional SMARTrial.
- Source :
-
Nature cancer [Nat Cancer] 2023 Dec; Vol. 4 (12), pp. 1648-1659. Date of Electronic Publication: 2023 Oct 02. - Publication Year :
- 2023
-
Abstract
- Ex vivo drug response profiling is a powerful tool to study genotype-drug response associations and is being explored as a tool set for precision medicine in cancer. Here we conducted a prospective non-interventional trial to investigate feasibility of ex vivo drug response profiling for treatment guidance in hematologic malignancies (SMARTrial, NCT03488641 ). The primary endpoint to provide drug response profiling reports within 7 d was met in 91% of all study participants (N = 80). Secondary endpoint analysis revealed that ex vivo resistance to chemotherapeutic drugs predicted chemotherapy treatment failure in vivo. We confirmed the predictive value of ex vivo response to chemotherapy in a validation cohort of 95 individuals with acute myeloid leukemia treated with daunorubicin and cytarabine. Ex vivo drug response profiles improved ELN-22 risk stratification in individuals with adverse risk. We conclude that ex vivo drug response profiling is clinically feasible and has the potential to predict chemotherapy response in individuals with hematologic malignancies beyond clinically established genetic markers.<br /> (© 2023. The Author(s).)
- Subjects :
- Humans
Cytarabine therapeutic use
Daunorubicin therapeutic use
Prospective Studies
Antibiotics, Antineoplastic therapeutic use
Antimetabolites, Antineoplastic therapeutic use
Treatment Outcome
Hematologic Neoplasms drug therapy
Hematologic Neoplasms genetics
Leukemia, Myeloid, Acute drug therapy
Leukemia, Myeloid, Acute genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2662-1347
- Volume :
- 4
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature cancer
- Publication Type :
- Academic Journal
- Accession number :
- 37783805
- Full Text :
- https://doi.org/10.1038/s43018-023-00645-5