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Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis.
- Source :
-
Progress in neurobiology [Prog Neurobiol] 2023 Dec; Vol. 231, pp. 102532. Date of Electronic Publication: 2023 Sep 27. - Publication Year :
- 2023
-
Abstract
- Multiple sclerosis (MS) pathology features autoimmune-driven neuroinflammation, demyelination, and failed remyelination. Carnosine is a histidine-containing dipeptide (HCD) with pluripotent homeostatic properties that is able to improve outcomes in an animal MS model (EAE) when supplied exogenously. To uncover if endogenous carnosine is involved in, and protects against, MS-related neuroinflammation, demyelination or remyelination failure, we here studied the HCD-synthesizing enzyme carnosine synthase (CARNS1) in human MS lesions and two preclinical mouse MS models (EAE, cuprizone). We demonstrate that due to its presence in oligodendrocytes, CARNS1 expression is diminished in demyelinated MS lesions and mouse models mimicking demyelination/inflammation, but returns upon remyelination. Carns1-KO mice that are devoid of endogenous HCDs display exaggerated neuroinflammation and clinical symptoms during EAE, which could be partially rescued by exogenous carnosine treatment. Worsening of the disease appears to be driven by a central, not peripheral immune-modulatory, mechanism possibly linked to impaired clearance of the reactive carbonyl acrolein in Carns1-KO mice. In contrast, CARNS1 is not required for normal oligodendrocyte precursor cell differentiation and (re)myelin to occur, and neither endogenous nor exogenous HCDs protect against cuprizone-induced demyelination. In conclusion, the loss of CARNS1 from demyelinated MS lesions can aggravate disease progression through weakening the endogenous protection against neuroinflammation.<br />Competing Interests: Declaration of Competing Interest None.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Mice
Animals
Cuprizone adverse effects
Cuprizone metabolism
Neuroinflammatory Diseases
Myelin Sheath pathology
Oligodendroglia pathology
Disease Models, Animal
Multiple Sclerosis drug therapy
Carnosine adverse effects
Carnosine metabolism
Encephalomyelitis, Autoimmune, Experimental chemically induced
Encephalomyelitis, Autoimmune, Experimental metabolism
Encephalomyelitis, Autoimmune, Experimental pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5118
- Volume :
- 231
- Database :
- MEDLINE
- Journal :
- Progress in neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 37774767
- Full Text :
- https://doi.org/10.1016/j.pneurobio.2023.102532