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Ultrabright Fluorescent Nanorod-Based Immunochromatographic with Low Background for Advancing Detection Performance.
- Source :
-
Analytical chemistry [Anal Chem] 2023 Nov 14; Vol. 95 (45), pp. 16585-16592. Date of Electronic Publication: 2023 Sep 29. - Publication Year :
- 2023
-
Abstract
- Nanomaterials-based immunochromatographic assays (ICAs) are of great significance in point-of-care testing (POCT), yet it remains challenging to explore low background platforms and high chromogenic intensity probes to improve detection performance. Herein, we reported a low interference and high signal-to-noise ratio fluorescent ICA platform based on ultrabright persistent luminescent nanoparticles (PLNPs) Zn <subscript>2</subscript> GeO <subscript>4</subscript> : Mn, which could produce intense photoluminescence at 254 nm excitation to reduce background interference from ICA substrates and samples. The prepared immunosensor was successfully applied in T-2 toxin detection with a remarkable limit of detection of 0.025 ng/mL, which was 22-fold more sensitive compared with that of traditional gold nanoparticles. Ultimately, a portable 3D-printed detection device equipped with a smartphone analyzing application was fabricated for quantitative readout in POCT, achieving favorable recoveries in practical sample detection. This work provides a creative attempt for ultrabright PLNP-based low background ICA, and it also guarantees its feasibility in practical POCT.
Details
- Language :
- English
- ISSN :
- 1520-6882
- Volume :
- 95
- Issue :
- 45
- Database :
- MEDLINE
- Journal :
- Analytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 37774142
- Full Text :
- https://doi.org/10.1021/acs.analchem.3c02718