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First-in-human liver transplantation from a centenarian deceased donor after brain death.

Authors :
De Simone P
Ghinolfi D
Palladino S
Catalano G
Martinelli C
Ducci J
Bronzoni J
Tincani G
Balzano E
Carrai P
Petruccelli S
Campani D
Crocetti L
Lazzeri C
Biancofiore G
Peris A
Source :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2024 Feb; Vol. 24 (2), pp. 304-307. Date of Electronic Publication: 2023 Sep 25.
Publication Year :
2024

Abstract

Liver transplantation from elderly donors is expanding due to demand for liver grafts, aging of recipients and donors, and introduction of machine perfusion. We report on a liver transplant from a 100-year-old deceased donor after brain death. The liver was transplanted after the use of hypothermic machine perfusion to a 60-year-old recipient with advanced hepatocellular carcinoma undergoing neoadjuvant immunotherapy. Nine months after the transplant, the patient is alive with a functioning graft and no evidence of acute rejection or tumor recurrence.<br /> (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1600-6143
Volume :
24
Issue :
2
Database :
MEDLINE
Journal :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Publication Type :
Report
Accession number :
37757913
Full Text :
https://doi.org/10.1016/j.ajt.2023.09.014