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Early cumulus cell removal increases cumulative live birth rate while having no negative effect on the malformation rate in in vitro fertilization: a propensity score-matched cohort study.

Authors :
Sun LJ
Liang SS
Liu MH
Pan JP
Huang MY
Teng XM
Wu HX
Source :
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2024 Jan; Vol. 309 (1), pp. 287-293. Date of Electronic Publication: 2023 Sep 27.
Publication Year :
2024

Abstract

Purpose: The aim of this study was to investigate the efficacy and safety of early cumulus cell removal (ECCR) during human in vitro fertilization (IVF).<br />Methods: A retrospective analysis was performed between January 2011 and December 2019. The study enrolled 1131 couples who underwent IVF treatment with ECCR. After propensity score matching at a 1:1 ratio, 1131 couples who underwent overnight coincubation of gametes were selected. The main outcome measure was the cumulative live birth rate. Secondary outcome measures included the cumulative pregnancy rate, polyspermy rate, available embryo rate, miscarriage rate, malformation rate, time to live birth, and oocyte-to-baby rate.<br />Results: There were no significant differences found between the two groups in the polyspermy rate, available embryo rate, miscarriage rate, time to live birth, oocyte-to-baby rate, and neonatal congenital anomalies rate. The results of the study showed that ECCR was associated with a significantly higher cumulative live birth rate and cumulative pregnancy rate, along with a significantly lower fertilization rate.<br />Conclusions: ECCR tended to confer increased cumulative live birth rate and had no negative effect on the neonatal malformation rate.<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Details

Language :
English
ISSN :
1432-0711
Volume :
309
Issue :
1
Database :
MEDLINE
Journal :
Archives of gynecology and obstetrics
Publication Type :
Academic Journal
Accession number :
37755532
Full Text :
https://doi.org/10.1007/s00404-023-07212-4