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Intraoperative electrochemotherapy of the posterior resection surface after pancreaticoduodenectomy: Preliminary results of a hybrid approach treatment of pancreatic cancer.

Authors :
Čebron Ž
Djokić M
Petrič M
Čemažar M
Bošnjak M
Serša G
Trotovšek B
Source :
Bioelectrochemistry (Amsterdam, Netherlands) [Bioelectrochemistry] 2024 Feb; Vol. 155, pp. 108576. Date of Electronic Publication: 2023 Sep 22.
Publication Year :
2024

Abstract

Background: Despite extensive research in recent decades, pancreatic cancer continues to be among the most lethal forms of cancer, with no substantial increase in survival rates. Local recurrences account for approximately 30 per cent of all disease recurrences. With the intent to improve survival, we designed a novel, hybrid treatment strategy consisting of surgical resection and additional intraoperative electrochemotherapy of the posterior resection surface. We present the study protocols and preliminary findings of a prospective pilot study investigating this treatment approach.<br />Methods: Consenting patients with resectable pancreatic head ductal adenocarcinoma who met the inclusion criteria were enrolled in the study. After surgical resection, electrochemotherapy with bleomycin was performed using plate electrodes to cover the area between anatomical landmarks.<br />Results: Electrochemotherapy of the posterior resection surface was feasible in all 7 patients. We observed pancreatic fistula grade B in only one patient; all other noted complications were Clavien-Dindo grade 2 or less. The hospital mortality was 0%.<br />Conclusions: Our preliminary results suggest that a hybrid approach combining surgery with intraoperative electrochemotherapy is safe and feasible.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1878-562X
Volume :
155
Database :
MEDLINE
Journal :
Bioelectrochemistry (Amsterdam, Netherlands)
Publication Type :
Academic Journal
Accession number :
37748261
Full Text :
https://doi.org/10.1016/j.bioelechem.2023.108576