Effect of amitriptyline on laminar differentiation of neonatal rat olfactory bulb.

Amitriptyline (AT) was injected i.p. (0.01 g/kg) into newborn rats for 12 days. Stereometric measurements of coronal sections of the olfactory bulbs showed that the area of the external plexiform layer (EPL) in the AT-treated group was significantly smaller than that of control rats. Rats treated with AT also showed a significantly lower increase in body weight compared with the saline-injected control group.