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An innate immune sensor wandering around - NOD1 promotes cell migration via non-canonical signaling.
- Source :
-
The FEBS journal [FEBS J] 2023 Nov; Vol. 290 (22), pp. 5292-5294. Date of Electronic Publication: 2023 Sep 21. - Publication Year :
- 2023
-
Abstract
- NOD1 is a cytosolic immune receptor well known for recognizing intracellular bacteria and inducing innate immune responses. Upon ligand binding, it usually forms a complex with the serine/threonine kinase RIPK2 to activate the transcription factor NF-κB. Next to its role in pathogen recognition, NOD1 has been associated with cancer progression. In this regard, Hezinger et al. investigated a non-canonical role of NOD1 in cell migration. They discovered that NOD1 is crucial for the migration and chemotaxis of HeLa cells and identified HAX-1 as a novel interaction partner.<br /> (© 2023 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
Details
- Language :
- English
- ISSN :
- 1742-4658
- Volume :
- 290
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- The FEBS journal
- Publication Type :
- Academic Journal
- Accession number :
- 37735823
- Full Text :
- https://doi.org/10.1111/febs.16952