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An innate immune sensor wandering around - NOD1 promotes cell migration via non-canonical signaling.

Authors :
Schmitz I
Mühlen S
Source :
The FEBS journal [FEBS J] 2023 Nov; Vol. 290 (22), pp. 5292-5294. Date of Electronic Publication: 2023 Sep 21.
Publication Year :
2023

Abstract

NOD1 is a cytosolic immune receptor well known for recognizing intracellular bacteria and inducing innate immune responses. Upon ligand binding, it usually forms a complex with the serine/threonine kinase RIPK2 to activate the transcription factor NF-κB. Next to its role in pathogen recognition, NOD1 has been associated with cancer progression. In this regard, Hezinger et al. investigated a non-canonical role of NOD1 in cell migration. They discovered that NOD1 is crucial for the migration and chemotaxis of HeLa cells and identified HAX-1 as a novel interaction partner.<br /> (© 2023 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)

Details

Language :
English
ISSN :
1742-4658
Volume :
290
Issue :
22
Database :
MEDLINE
Journal :
The FEBS journal
Publication Type :
Academic Journal
Accession number :
37735823
Full Text :
https://doi.org/10.1111/febs.16952