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Nanoformulation of a novel potent ebselen analog for treatment of vulvovaginal candidiasis.
- Source :
-
Nanomedicine (London, England) [Nanomedicine (Lond)] 2023 Aug; Vol. 18 (18), pp. 1195-1206. Date of Electronic Publication: 2023 Sep 19. - Publication Year :
- 2023
-
Abstract
- Background: Vulvovaginal candidiasis is primarily caused by Candida albicans ( C. albicans ). Here, a novel organoselenium compound (G20) was synthesized and evaluated for anti- Candida activity. Methods: Growth-inhibition studies and medium acidification assays to assess the inhibition of the yeast plasma membrane H <superscript>+</superscript> -ATPase (Pma1p) were carried out in vitro using G20. A self-nanoemulsifying formulation (SNEP) of G20 was prepared and evaluated for antimycotic activity in a mouse model. Results: G20 inhibited the growth of C. albicans through a mechanism that, at least in part, involves the inhibition of Pma1p. The G20-SNEP formulation significantly reduced vaginal colonization and vaginal inflammation relative to yeast-infected but untreated control mice. Conclusion: G20-SNEP exhibits potent antimycotic activity in a mouse model of vulvovaginal candidiasis.
Details
- Language :
- English
- ISSN :
- 1748-6963
- Volume :
- 18
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Nanomedicine (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 37724540
- Full Text :
- https://doi.org/10.2217/nnm-2022-0323