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Molecular docking analysis of Indole based diaza-sulphonamides with JAK-3 protein.
- Source :
-
Bioinformation [Bioinformation] 2023 Jan 31; Vol. 19 (1), pp. 74-78. Date of Electronic Publication: 2023 Jan 31 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- JAK-3 gene is a part of an important signalling pathway in oral cancer. Therefore, it is of interest to evaluate the inhibitory properties of new indole based diaza-sulphonamides compounds against JAK3 gene. Molecular docking analysis showed that among the selected compounds (1-9), the compounds 1-4 turned out to be the most potentially capable ones to be used as ant-cancer drugs. Also, they are proved to be non-toxic.<br />Competing Interests: The authors declare that there is no conflict of interests.<br /> (© 2023 Biomedical Informatics.)
Details
- Language :
- English
- ISSN :
- 0973-2063
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioinformation
- Publication Type :
- Academic Journal
- Accession number :
- 37720295
- Full Text :
- https://doi.org/10.6026/97320630019074