A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.

Authors :: Hubert CG
Stauffer SR
Lathia JD
Source :: PLoS biology [PLoS Biol] 2023 Sep 15; Vol. 21 (9), pp. e3002295. Date of Electronic Publication: 2023 Sep 15 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.<br />Competing Interests: The authors have declared that no competing interests exist.<br /> (Copyright: © 2023 Hubert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Subjects :: Humans
Epigenesis, Genetic
Neoplastic Stem Cells
Phenotype
ATP Binding Cassette Transporter, Subfamily G, Member 2
Neoplasm Proteins
Intracellular Signaling Peptides and Proteins
Drug Resistance, Neoplasm genetics
Colonic Neoplasms drug therapy
Colonic Neoplasms genetics

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