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Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study.
- Source :
-
BioMed research international [Biomed Res Int] 2023 Sep 06; Vol. 2023, pp. 2594664. Date of Electronic Publication: 2023 Sep 06 (Print Publication: 2023). - Publication Year :
- 2023
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Abstract
- Background: Recent researches have failed to uncover a clear explanation for proton pump inhibitors' bone-loss effects. In light of pantoprazole's effects on gastrin secretion, the goal of this study was to see if it caused bone loss through gastrin secretion.<br />Methods: Forty male rats were divided into control, octreotide (Oct), pantoprazole (Pan), and pantoprazole plus octreotide (Pan+Oct) groups. Serum calcium, phosphorous, alkaline phosphatase, parathyroid hormone, and gastrin were measured before and three months after the treatment, and bone densitometry was examined. The rats' femoral bones were examined stereologically at the end of the investigation.<br />Results: The Pan group had considerably greater levels of serum alkaline phosphatase, parathyroid hormone (PTH), and gastrin, but this was prevented in the presence of Oct, a gastrin secretion inhibitor. All parameters of femoral bone densitometry in the Pan group were significantly lower than the control after treatment which was considerably inhibited in the presence of Oct. Furthermore, when compared to the control and Oct groups, the rats in the Pan group had a lower trabecular volume, femur bone weight, and volume, as well lower number of osteocytes. The amount of osteoclasts, on the other hand, was much higher in the Pan group than in the other groups.<br />Conclusion: Overall findings revealed that pantoprazole caused bone loss, which could be prevented by adding octreotide. Because these detrimental effects were not detected in rats given both Oct and Pan, it was suggested that the effect of Pan on bone was produced by a hypergastrinemic condition.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Copyright © 2023 Forough Saki et al.)
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2023
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 37711876
- Full Text :
- https://doi.org/10.1155/2023/2594664