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Early-childhood linear growth faltering in low- and middle-income countries.

Authors :
Benjamin-Chung J
Mertens A
Colford JM Jr
Hubbard AE
van der Laan MJ
Coyle J
Sofrygin O
Cai W
Nguyen A
Pokpongkiat NN
Djajadi S
Seth A
Jilek W
Jung E
Chung EO
Rosete S
Hejazi N
Malenica I
Li H
Hafen R
Subramoney V
Häggström J
Norman T
Brown KH
Christian P
Arnold BF
Source :
Nature [Nature] 2023 Sep; Vol. 621 (7979), pp. 550-557. Date of Electronic Publication: 2023 Sep 13.
Publication Year :
2023

Abstract

Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards) <superscript>1,2</superscript> . Stunting, a form of linear growth faltering, increases the risk of illness, impaired cognitive development and mortality. Global stunting estimates rely on cross-sectional surveys, which cannot provide direct information about the timing of onset or persistence of growth faltering-a key consideration for defining critical windows to deliver preventive interventions. Here we completed a pooled analysis of longitudinal studies in low- and middle-income countries (n = 32 cohorts, 52,640 children, ages 0-24 months), allowing us to identify the typical age of onset of linear growth faltering and to investigate recurrent faltering in early life. The highest incidence of stunting onset occurred from birth to the age of 3 months, with substantially higher stunting at birth in South Asia. From 0 to 15 months, stunting reversal was rare; children who reversed their stunting status frequently relapsed, and relapse rates were substantially higher among children born stunted. Early onset and low reversal rates suggest that improving children's linear growth will require life course interventions for women of childbearing age and a greater emphasis on interventions for children under 6 months of age.<br /> (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)

Details

Language :
English
ISSN :
1476-4687
Volume :
621
Issue :
7979
Database :
MEDLINE
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
37704719
Full Text :
https://doi.org/10.1038/s41586-023-06418-5