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Mechanical factors driving cancer progression.
- Source :
-
Advances in cancer research [Adv Cancer Res] 2023; Vol. 160, pp. 61-81. Date of Electronic Publication: 2023 Jul 16. - Publication Year :
- 2023
-
Abstract
- A fundamental step of tumor metastasis is tumor cell migration away from the primary tumor site. One mode of migration that is essential but still understudied is collective invasion, the process by which clusters of cells move in a coordinated fashion. In recent years, there has been growing interest to understand factors regulating collective invasion, with increasing number of studies investigating the biomechanical regulation of collective invasion. In this review we discuss the dynamic relationship between tumor microenvironment cues and cell response by first covering mechanical factors in the microenvironment and second, discussing the mechanosensing pathways utilized by cells in collective clusters to dynamically respond to mechanical matrix cues. Finally, we discuss model systems that have been developed which have increased our understanding of the mechanical factors contributing to tumor progression.<br /> (Copyright © 2023. Published by Elsevier Inc.)
- Subjects :
- Humans
Tumor Microenvironment
Models, Biological
Neoplasms
Subjects
Details
- Language :
- English
- ISSN :
- 2162-5557
- Volume :
- 160
- Database :
- MEDLINE
- Journal :
- Advances in cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 37704291
- Full Text :
- https://doi.org/10.1016/bs.acr.2023.06.002