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Hepatitis C Elimination in Moldova Is Feasible and Cost-Saving: A Modeling Study.

Authors :
Aaron A
Zhong H
Hiebert L
Zhuo Y
Adee M
Paraschiv A
Stratulat S
Ward JW
Chhatwal J
Source :
The Journal of infectious diseases [J Infect Dis] 2023 Sep 13; Vol. 228 (Suppl 3), pp. S189-S197.
Publication Year :
2023

Abstract

Background: Moldova, an upper-middle-income country in Eastern Europe, is facing a high burden of hepatitis C virus (HCV). Our objective was to assist the National Agency of Public Health of Moldova in planning to achieve the World Health Organization's HCV elimination goals by 2030.<br />Methods: This study adapted a previously developed microsimulation model to simulate the HCV epidemic in Moldova from 2004 to 2050. Model outcomes included temporal trends in HCV infection, prevalence, mortality, and total cost of care, including screening and treatment. We evaluated scenarios that could eliminate HCV by 2030.<br />Results: Multiple strategies could lead to HCV elimination in Moldova by 2030. A realistic scenario of a 20% annual screening and 80% treatment rate would require 2.75 million individuals to be screened and 65 000 treated by 2030. Compared to 2015, this program will reduce HCV incidence by 98% and HCV-related deaths by 72% in 2030. Between 2022 and 2030, this strategy would cost $17.5 million for HCV screening and treatment. However, by 2050, the health system would save >$85 million compared to no investment in elimination efforts.<br />Conclusions: HCV elimination in Moldova is feasible and can be cost saving, but requires resources to scale HCV screening and treatment.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
1537-6613
Volume :
228
Issue :
Suppl 3
Database :
MEDLINE
Journal :
The Journal of infectious diseases
Publication Type :
Academic Journal
Accession number :
37703345
Full Text :
https://doi.org/10.1093/infdis/jiad138