Analysis of Serum VEGF, IGF-1, and HIF-1α Levels in ADHD.

Objective: In recent years, it has been emphasized that various growth factors that affect neurogenesis may lead to ADHD. In this study, we aimed to investigate the role of VEGF, IGF-1, and HIF-1α growth factors in the etiopathogenesis of ADHD.
Method: Levels of VEGF, IGF-1, and HIF-1α were compared between 40 ADHD children and 40 healthy children, aged 7 to 13 years.
Result: VEGF, IGF-1, and HIF-1α levels did not significantly differ between the groups. There was a negative correlation between serum VEGF levels and the parent-rated T-DSM-IV-S (AD) subscale. There was a positive correlation between serum IGF-1 levels and the parent-rated T-DSM-IV-S (AD) subscale, and SDQ (ES) subscale.
Conclusion: Given our limitations and the fact that some of our findings differ from those of other studies, it is evident that this area requires additional research with larger samples.
Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.