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Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: A Campus ALL study.
- Source :
-
British journal of haematology [Br J Haematol] 2023 Nov; Vol. 203 (4), pp. 637-650. Date of Electronic Publication: 2023 Sep 12. - Publication Year :
- 2023
-
Abstract
- Blinatumomab is the first bi-specific T-cell engager approved for relapsed or refractory B-cell precursor acute lymphoblastic leukaemia (B-ALL). Despite remarkable clinical results, the effects of blinatumomab on the host immune cell repertoire are not fully elucidated. In the present study, we characterized the peripheral blood (PB) and, for the first time, the bone marrow (BM) immune cell repertoire upon blinatumomab treatment. Twenty-nine patients with B-ALL received blinatumomab according to clinical practice. Deep multiparametric flow cytometry was used to characterize lymphoid subsets during the first treatment cycle. Blinatumomab induced a transient redistribution of PB effector T-cell subsets and Treg cells with a persistent increase in cytotoxic NK cells, which was associated with a transient upregulation of immune checkpoint receptors on PB CD4 and CD8 T-cell subpopulations and of CD39 expression on suppressive Treg cells. Of note, BM immune T-cell subsets showed a broader post-treatment subversion, including the modulation of markers associated with a T-cell-exhausted phenotype. In conclusion, our study indicates that blinatumomab differentially modulates the PB and BM immune cell repertoire, which may have relevant clinical implications in the therapeutic setting.<br /> (© 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
- Subjects :
- Humans
Bone Marrow metabolism
Remission Induction
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Antibodies, Bispecific pharmacology
Antibodies, Bispecific therapeutic use
Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 203
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 37700538
- Full Text :
- https://doi.org/10.1111/bjh.19104