Four undescribed triterpenes from the aerial parts of Verbena officinalis.

Authors :: Yang JY
Guo CS
Su L
Xu CX
Li RT
Zhong JD
Source :: Fitoterapia [Fitoterapia] 2023 Oct; Vol. 170, pp. 105670. Date of Electronic Publication: 2023 Sep 09.
Publication Year :: 2023
Abstract: Verbena officinalis is used as a Chinese folk medicine for the treatment of rheumatism and bronchitis. Herein, four undescribed triterpenes, officinalisoids A-D (1-4), together with thirty-three known compounds (5-37) were isolated from the aerial parts of V. officinalis. The chemical structures of the new compounds were determined by spectrometric data interpretation using NMR, HRESIMS, IR and UV spectroscopy. Biological evaluation results revealed that compound 30 exhibited potential anti-inflammatory activity with IC <subscript>50</subscript> value of 6.07 μM (CC <subscript>50</subscript>  > 50 μM) and compound 12 showed moderate anti-dengue virus activity with the IC <subscript>50</subscript> value of 24.55 μM (CC <subscript>50</subscript>  > 50 μM).<br />Competing Interests: Declaration of Competing Interest The authors report no declarations of interest.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)