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Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study.

Authors :
Yamamoto H
Tanaka S
Kasugai D
Shimizu M
Tsuchikawa Y
Hori Y
Fugane Y
Inoue T
Nagaya M
Omote N
Higashi M
Yamamoto T
Jingushi N
Numaguchi A
Goto Y
Nishida Y
Source :
Scientific reports [Sci Rep] 2023 Sep 04; Vol. 13 (1), pp. 14529. Date of Electronic Publication: 2023 Sep 04.
Publication Year :
2023

Abstract

This prospective observational cohort study was performed to investigate the physical function and mental health trajectories of novel coronavirus disease 2019 (COVID-19) patients requiring invasive mechanical ventilation (IMV) after discharge from the intensive care unit (ICU). The study population consisted of 64 patients (median age, 60 years; 85.9% male; median IMV duration, 9 days). At ICU discharge, 28.1% of the patients had Medical Research Council (MRC) sum score < 48 points, and prolonged IMV was significantly associated with lower MRC sum score and handgrip strength. Symptoms were similar between groups at ICU discharge, and the symptoms most commonly reported as moderate-to-severe were impaired well-being (52%), anxiety (43%), tiredness (41%), and depression (35%). Although muscle strength and mobility status were significantly improved after ICU discharge, Edmonton Symptom Assessment System score did not improve significantly in the prolonged IMV group. EuroQol five-dimension five-level summary index was significantly lower in the prolonged than short IMV group at 6 months after ICU discharge. We found substantial negative physical function and mental health consequences in the majority of surviving COVID-19 patients requiring IMV, with prolonged period of IMV showing greater negative effects not only immediately but also at 6 months after discharge from the ICU.<br /> (© 2023. Springer Nature Limited.)

Details

Language :
English
ISSN :
2045-2322
Volume :
13
Issue :
1
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
37666912
Full Text :
https://doi.org/10.1038/s41598-023-41684-3