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BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma.

Authors :
Wang J
Chen A
Xue Z
Liu J
He Y
Liu G
Zhao Z
Li W
Zhang Q
Chen A
Wang J
Li X
Wang X
Huang B
Source :
Cell death & disease [Cell Death Dis] 2023 Sep 02; Vol. 14 (9), pp. 585. Date of Electronic Publication: 2023 Sep 02.
Publication Year :
2023

Abstract

There is an urgent need for novel diagnostic and therapeutic strategies for patients with Glioblastoma multiforme (GBM). Previous studies have shown that BCL2 like 13 (BCL2L13) is a member of the BCL2 family regulating cell growth and apoptosis in different types of tumors. However, the clinical significance, biological role, and potential mechanism in GBM remain unexplored. In this study, we showed that BCL2L13 expression is significantly upregulated in GBM cell lines and clinical GBM tissue samples. Mechanistically, BCL2L13 targeted DNM1L at the Ser616 site, leading to mitochondrial fission and high mitophagy flux. Functionally, these alterations significantly promoted the proliferation and invasion of GBM cells both in vitro and in vivo. Overall, our findings demonstrated that BCL2L13 plays a significant role in promoting mitophagy via DNM1L-mediated mitochondrial fission in GBM. Therefore, the regulation and biological function of BCL2L13 render it a candidate molecular target for treating GBM.<br /> (© 2023. The Author(s).)

Details

Language :
English
ISSN :
2041-4889
Volume :
14
Issue :
9
Database :
MEDLINE
Journal :
Cell death & disease
Publication Type :
Academic Journal
Accession number :
37660127
Full Text :
https://doi.org/10.1038/s41419-023-06112-4