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Antitumor and chemopreventive role of major phytochemicals against breast cancer development.
- Source :
-
Natural product research [Nat Prod Res] 2024 Oct; Vol. 38 (20), pp. 3623-3643. Date of Electronic Publication: 2023 Aug 30. - Publication Year :
- 2024
-
Abstract
- Breast cancer continues to be one of the most commonly diagnosed cancers around the world. Despite the decrease in mortality, there has been a steady increase in its incidence. There is much evidence that naturally occurring phytochemicals could prove to be safer alternatives aimed at prevention and development of breast cancer. In the present review, we discuss important phytochemicals, namely capsaicin, alpha-santalol and diallyl trisulphide that are shown to have chemopreventive and anti-tumour properties against breast cancer development. We examined current knowledge of their bioavailability, safety and modulation of molecular mechanisms including their ability to induce apoptotic cell death, promote cell cycle arrest, and inhibit cellular proliferation in different breast cancer cell lines and in vivo models. This review emphasises the importance of these naturally occurring phytochemicals and their potential of becoming therapeutic options in the arsenal against breast cancer development provided further scientific and clinical validation.
- Subjects :
- Humans
Female
Antineoplastic Agents, Phytogenic pharmacology
Antineoplastic Agents, Phytogenic chemistry
Apoptosis drug effects
Cell Proliferation drug effects
Cell Line, Tumor
Animals
Polycyclic Sesquiterpenes pharmacology
Allyl Compounds pharmacology
Sesquiterpenes pharmacology
Sesquiterpenes chemistry
Sesquiterpenes therapeutic use
Breast Neoplasms drug therapy
Breast Neoplasms prevention & control
Phytochemicals pharmacology
Capsaicin pharmacology
Capsaicin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 38
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 37646820
- Full Text :
- https://doi.org/10.1080/14786419.2023.2251167