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Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET.
- Source :
-
Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2023 Aug 28; Vol. 15 (3), pp. e12391. Date of Electronic Publication: 2023 Aug 28 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- Introduction: [18F]AZD4694 is an amyloid beta (Aβ) imaging agent used in several observational studies and clinical trials. However, no studies have yet published data on longitudinal Aβ accumulation measured with [18F]AZD4694.<br />Methods: We assessed 146 individuals who were evaluated with [18F]AZD4694 at baseline and 2-year follow-up. We calculated annual rates of [18F]AZD4694 change for clinically defined and biomarker-defined groups.<br />Results: Cognitively unimpaired (CU) older adults displayed subtle [18F]AZD4694 standardized uptake value ratio (SUVR) accumulation over the follow-up period. In contrast, Aβ positive CU older adults displayed higher annual [18F]AZD4694 SUVR increases. [18F]AZD4694 SUVR accumulation in Aβ positive mild cognitive impairment (MCI) and dementia was modest across the neocortex.<br />Discussion: Larger increases in [18F]AZD4694 SUVR were observed in CU individuals who had abnormal amyloid positron emission tomography levels at baseline. [18F]AZD4694 can be used to monitor Aβ levels in therapeutic trials as well as clinical settings, particularly prior to initiating anti-amyloid therapies.<br />Competing Interests: No conflicts of interest relevant to this article exist.<br /> (© 2023 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.)
Details
- Language :
- English
- ISSN :
- 2352-8729
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 37644990
- Full Text :
- https://doi.org/10.1002/dad2.12391