Back to Search
Start Over
Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila.
- Source :
-
Nature communications [Nat Commun] 2023 Aug 30; Vol. 14 (1), pp. 5280. Date of Electronic Publication: 2023 Aug 30. - Publication Year :
- 2023
-
Abstract
- Sensory systems are dynamically adjusted according to the animal's ongoing needs by neuromodulators, such as neuropeptides. Neuropeptides are often widely-distributed throughout sensory networks, but it is unclear whether such neuropeptides uniformly modulate network activity. Here, we leverage the Drosophila antennal lobe (AL) to resolve whether myoinhibitory peptide (MIP) uniformly modulates AL processing. Despite being uniformly distributed across the AL, MIP decreases olfactory input to some glomeruli, while increasing olfactory input to other glomeruli. We reveal that a heterogeneous ensemble of local interneurons (LNs) are the sole source of AL MIP, and show that differential expression of the inhibitory MIP receptor across glomeruli allows MIP to act on distinct intraglomerular substrates. Our findings demonstrate how even a seemingly simple case of modulation can have complex consequences on network processing by acting non-uniformly within different components of the overall network.<br /> (© 2023. Springer Nature Limited.)
- Subjects :
- Animals
Gene Expression
Interneurons
Drosophila
Smell
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 37644052
- Full Text :
- https://doi.org/10.1038/s41467-023-41012-3