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[ 15 O]H 2 O PET: Potential or Essential for Molecular Imaging?

Authors :: Slart RHJA
Martinez-Lucio TS
Boersma HH
Borra RH
Cornelissen B
Dierckx RAJO
Dobrolinska M
Doorduin J
Erba PA
Glaudemans AWJM
Giacobbo BL
Luurtsema G
Noordzij W
van Sluis J
Tsoumpas C
Lammertsma AA
Source :: Seminars in nuclear medicine [Semin Nucl Med] 2024 Sep; Vol. 54 (5), pp. 761-773. Date of Electronic Publication: 2023 Aug 26.
Publication Year :: 2024
Abstract: Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and oxygenation. Although water PET has a long history, its true potential has not made it into regular clinical practice. The article highlights the potential of water PET in molecular imaging and suggests its prospective role in becoming an essential tool for the 21st century precision medicine in different domains ranging from preclinical to clinical research and practice. The recent technical advances in high-sensitivity PET imaging can play a key accelerating role in empowering this technique, though there are still several challenges to overcome.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)