Back to Search
Start Over
Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment.
- Source :
-
Biomaterials research [Biomater Res] 2023 Aug 28; Vol. 27 (1), pp. 81. Date of Electronic Publication: 2023 Aug 28. - Publication Year :
- 2023
-
Abstract
- Background: Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy.<br />Main Body: Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges.<br />Conclusion: This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment.<br /> (© 2023. The Korean Society for Biomaterials.)
Details
- Language :
- English
- ISSN :
- 1226-4601
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biomaterials research
- Publication Type :
- Academic Journal
- Accession number :
- 37635253
- Full Text :
- https://doi.org/10.1186/s40824-023-00418-2