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A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2023 Sep 06; Vol. 15 (35), pp. 41224-41236. Date of Electronic Publication: 2023 Aug 24. - Publication Year :
- 2023
-
Abstract
- Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth-manganese core-shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnO <subscript> x </subscript> , was designed for 4T1 tumor theranostics in vitro and in vivo . The BDS-GOx@MnO <subscript> x </subscript> nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnO <subscript> x </subscript> nanozymes have also been systematically studied and revealed.
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 15
- Issue :
- 35
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 37615578
- Full Text :
- https://doi.org/10.1021/acsami.3c05412