The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not K Ca 1.1 channel expression.

The aim of this study was to understand the expression of big potassium (BK, K _Ca 1.1) channels in epileptic seizures under magnetic field application. Forty Wistar albino adult male rats were divided into five groups ( n  = 8). First group rats were control group. Pentylenetetrazole (PTZ) administrated to second group rats to induce the seizures with 35 mg/kg intraperitoneally injection every two days. Levetiracetam (LEV) i.p. at a dose of 108 mg/kg was given to third group rats as positive control group (PC) before 20 minutes PTZ administration. Pulsed magnetic field with 1.5 mT was exposed to the fourth group rats for 3 hours a day for 1 month as magnetic field (MF) group. 1.5 mT pulsed magnetic field was exposed to the fifth group rats for 3 hours a day for 1 month in addition to PTZ administration (PTZ+MF). K _Ca 1.1 not changed in hippocampus of PTZ rats while increased in frontal cortex and pons for PTZ group but not changed with magnetic field exposure. K _Ca 1.1 increased in heart of PTZ animals and turned back to mean control values with magnetic field exposure. Suppressing the expected increase of c-fos protein expression in seizures with magnetic field application but not being able to change the K _Ca 1.1 expression shows that new studies can be done by increasing the frequency of 1.5 mT magnetic field.