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Reprogramming dendritic cells through the immunological synapse: A two-way street.
- Source :
-
European journal of immunology [Eur J Immunol] 2023 Nov; Vol. 53 (11), pp. e2350393. Date of Electronic Publication: 2023 Sep 07. - Publication Year :
- 2023
-
Abstract
- Dendritic cells (DCs) bridge innate and adaptive immunity. Their main function is to present antigens to prime T cells and initiate and shape adaptive responses. Antigen presentation takes place through intimate contacts between the two cells, termed immune synapses (IS). During the formation of IS, information travels towards the T-cell side to induce and tune its activation; but it also travels in reverse via engagement of membrane receptors and within extracellular vesicles transferred to the DC. Such reverse information transfer and its consequences on DC fate have been largely neglected. Here, we review the events and effects of IS-mediated antigen presentation on DCs. In addition, we discuss novel technological advancements that enable monitoring DCs interactions with T lymphocytes, the main effects of DCs undergoing productive IS (postsynaptic DCs, or psDCs), and how reverse information transfer could be harnessed to modulate immune responses for therapeutic intervention.<br /> (© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)
- Subjects :
- T-Lymphocytes
Antigen Presentation
Antigens
Immunological Synapses
Dendritic Cells
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4141
- Volume :
- 53
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 37598303
- Full Text :
- https://doi.org/10.1002/eji.202350393