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BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis.
- Source :
-
Blood [Blood] 2023 Nov 02; Vol. 142 (18), pp. 1570-1575. - Publication Year :
- 2023
-
Abstract
- In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.<br /> (© 2023 by The American Society of Hematology.)
- Subjects :
- Humans
Adult
Proto-Oncogene Proteins B-raf genetics
Retrospective Studies
Incidence
Mutation
Neoplasms, Second Primary epidemiology
Neoplasms, Second Primary genetics
Histiocytosis, Langerhans-Cell epidemiology
Histiocytosis, Langerhans-Cell genetics
Histiocytosis, Langerhans-Cell pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 142
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 37595284
- Full Text :
- https://doi.org/10.1182/blood.2023021212