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Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Aug 31; Vol. 59 (71), pp. 10660-10663. Date of Electronic Publication: 2023 Aug 31. - Publication Year :
- 2023
-
Abstract
- Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 59
- Issue :
- 71
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 37581279
- Full Text :
- https://doi.org/10.1039/d3cc03363e