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Small molecule inhibitors of the fosfomycin resistance enzyme FosM from Mycobacterium abscessus.
- Source :
-
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2023 Oct; Vol. 1867 (10), pp. 130444. Date of Electronic Publication: 2023 Aug 12. - Publication Year :
- 2023
-
Abstract
- Fosfomycin is a safe broad-spectrum antibiotic that has not achieved widespread use because of the emergence of fosfomycin-modifying enzymes. Inhibition of fosfomycin-modifying enzymes could be used to help combat pathogens like Mycobacterium abscessus. Our previous work identified several inhibitors for the enzyme FosB from Staphylococcus aureus. We have tested those same compounds for inhibition of FosM, the fosfomycin-modifying enzyme from M. abscessus. The work described here will be used as the basis for more detailed studies into the inhibition of FosM.<br />Competing Interests: Declaration of Competing Interest There are no conflicts of interest to declare.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-8006
- Volume :
- 1867
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta. General subjects
- Publication Type :
- Academic Journal
- Accession number :
- 37579984
- Full Text :
- https://doi.org/10.1016/j.bbagen.2023.130444