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Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility.
- Source :
-
BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 06. Date of Electronic Publication: 2023 Aug 06. - Publication Year :
- 2023
-
Abstract
- Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.
Details
- Language :
- English
- ISSN :
- 2692-8205
- Database :
- MEDLINE
- Journal :
- BioRxiv : the preprint server for biology
- Accession number :
- 37577464
- Full Text :
- https://doi.org/10.1101/2023.08.03.551847