Back to Search Start Over

Research progress on the role of cationic amino acid transporter (CAT) family members in malignant tumors and immune microenvironment.

Authors :
You S
Han X
Xu Y
Yao Q
Source :
Amino acids [Amino Acids] 2023 Oct; Vol. 55 (10), pp. 1213-1222. Date of Electronic Publication: 2023 Aug 12.
Publication Year :
2023

Abstract

Amino acids are essential for the survival of all living organisms and living cells. Amino acid transporters mediate the transport and absorption of amino acids, and the dysfunction of these proteins can induce human diseases. Cationic amino acid transporters (CAT family, SLC7A1-4, and SLC7A14) are considered to be a group of transmembrane transporters, of which SLC7A1-3 are essential for arginine transport in mammals. Numerous studies have shown that CAT family-mediated arginine transport is involved in signal crosstalk between malignant tumor cells and immune cells, especially T cells. The modulation of extracellular arginine concentration has entered a number of clinical trials and achieved certain therapeutic effects. Here, we review the role of CAT family on tumor cells and immune infiltrating cells in malignant tumors and explore the therapeutic strategies to interfere with extracellular arginine concentration, to elaborate its application prospects. CAT family members may be used as biomarkers for certain cancer entities and might be included in new ideas for immunotherapy of malignant tumors.<br /> (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)

Details

Language :
English
ISSN :
1438-2199
Volume :
55
Issue :
10
Database :
MEDLINE
Journal :
Amino acids
Publication Type :
Academic Journal
Accession number :
37572157
Full Text :
https://doi.org/10.1007/s00726-023-03313-1