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Delayed ulceration following combination pulse dye laser and topical sirolimus treatment for port wine birthmarks: A case series.
- Source :
-
Pediatric dermatology [Pediatr Dermatol] 2024 Jan-Feb; Vol. 41 (1), pp. 108-111. Date of Electronic Publication: 2023 Aug 12. - Publication Year :
- 2024
-
Abstract
- Port wine birthmarks (PWB) are capillary vascular malformations within the papillary and reticular dermis, most commonly occurring on the head and neck and may darken and thicken with age. Pulsed dye laser (PDL) is the gold standard of treatment for PWB as it selectively targets involved vessels. Sirolimus is a macrolide antibiotic that selectively inhibits mammalian target of rapamycin, thereby suppressing the angiogenesis pathways that can be activated by PDL. Sirolimus and PDL may be used together to treat PWB. We present a case series describing three cases of delayed ulceration and systemic sirolimus absorption following combination therapy, highlighting a potential complication and patient safety concern.<br /> (© 2023 Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1525-1470
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric dermatology
- Publication Type :
- Report
- Accession number :
- 37571864
- Full Text :
- https://doi.org/10.1111/pde.15409