Polycythemia as an Uncommon Finding in 2 Children, One With Systemic Capillary Leak Syndrome and the Other With Protein-losing Enteropathy Caused by CD55 Deficiency.

Authors :: Kaya Z
Derinöz O
Source :: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2023 Nov 01; Vol. 45 (8), pp. e996-e1000. Date of Electronic Publication: 2023 Aug 07.
Publication Year :: 2023
Abstract: We report 2 children with distinct causes of polycythemia, 1 from systemic capillary leak syndrome (SCLS) and the other from protein-losing enteropathy (PLE) caused by CD55 deficiency. There is only a single case series about polycythemia in children with SCLS, but none on polycythemia in children with PLE. We present a 10-year-old girl with hypoalbuminemia, polycythemia, and edema who died as a result of an SCLS attack and a 1-year-old girl with PLE who was successfully treated with eculizumab. Our experience suggests that hematologists should be alert for SCLS and PLE in children with relative polycythemia.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Subjects :: Child
Female
Humans
Infant
Edema complications
CD55 Antigens metabolism
Capillary Leak Syndrome complications
Polycythemia complications
Protein-Losing Enteropathies etiology

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