Synthesis of 1-Aryltetralins via Re 2 O 7 /HReO 4 Mediated Intramolecular Hydroarylations.

Here, we describe highly efficient intramolecular hydroarylations mediated by Re ₂ O ₇ /HReO ₄ . Styrene derivatives of different electronic properties have been activated to effect a challenging intramolecular hydroarylation for the facile access to various substituted 1-aryltetralin structures. This method is characterized by mild reaction conditions, broad substrate scope, high chemical yields, and 100% atom economy. The potential synthetic application of this methodology was exemplified by the efficient total synthesis of an iso CA-4 analogue.