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Palladium-catalyzed coupling of amides and cyclopropanols for the synthesis of γ-diketones.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Aug 24; Vol. 59 (69), pp. 10392-10395. Date of Electronic Publication: 2023 Aug 24. - Publication Year :
- 2023
-
Abstract
- A palladium catalytic method has been developed for the coupling of amides and cyclopropanols to γ-diketones, through simultaneous C-N and C-C activation. Heteroatom ligand exchange and heteroatom-to-carbon ligation mode switching enable the achievement of molecular cross-coupling in an amide N-atom structural context-dependent manner, avoiding any stoichiometric organometallic reagent or base.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 59
- Issue :
- 69
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 37551733
- Full Text :
- https://doi.org/10.1039/d3cc02888g