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Oxidative Cleavage and Fluoromethylthiolation of C═C Bonds: A General Route toward Mono-, Di-, and Trifluoromethylthioesters from Alkenes.
- Source :
-
Organic letters [Org Lett] 2023 Aug 18; Vol. 25 (32), pp. 5984-5988. Date of Electronic Publication: 2023 Aug 07. - Publication Year :
- 2023
-
Abstract
- A novel oxidative cleavage and fluoromethylthiolation reaction of C═C bonds has been developed that represents the first and general method for the preparation of mono-, di-, and trifluoromethylthioesters from alkenes. The protocol features excellent product selectivity and substrate suitability. Various observations suggested that the protocol proceeded via a two-step radical process and that aldehyde was the key intermediate. What's more meaningful is that this route provides a new direction for converting alkenes into higher-value-added carbonyl-containing chemicals.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 25
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 37548642
- Full Text :
- https://doi.org/10.1021/acs.orglett.3c02101