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Efficacy of Percutaneous Coronary Intervention With Synergy Stents in Patients Aged ≥75 Years: 1-Year Clinical Outcomes from the Synergy Elderly Registry.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2023 Oct 01; Vol. 204, pp. 43-52. Date of Electronic Publication: 2023 Aug 01. - Publication Year :
- 2023
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Abstract
- Data regarding the clinical outcomes of older patients after Synergy everolimus-eluting stent (S-EES) implantation are limited. This study investigated the 12-month clinical outcomes of older patients who underwent percutaneous coronary intervention with new-generation drug-eluting stents according to ischemic risks. This prospective multicenter study targeted patients aged ≥75 years who underwent S-EES implantation. The primary and secondary end points included 12-month device-oriented composite end point (DOCE) (cardiovascular death, target vessel myocardial infarction, or target lesion revascularization) and major adverse cardiac and cerebrovascular events (MACCEs; all-cause death, myocardial infarction, target vessel revascularization, stent thrombosis, or stroke), respectively. A stratified analysis was conducted according to high-ischemic risk (HIR), defined as complex coronary intervention (number of stents implanted ≥3, total stented length >60 mm, chronic total occlusion, left main, or bifurcation), diabetes, or chronic kidney disease. In total, 650 enrolled patients aged ≥75 years were categorized into HIR (n = 425) and non-HIR groups (n = 225). In the total population, the 1-year incidence of DOCEs was 2.5%. The rates of DOCEs were not significantly different between the HIR and the non-HIR groups, whereas the MACCE rate was higher in the HIR (9.4%) than the non-HIR group (4.9%, p = 0.035), and the DOCE and MACCE components did not differ significantly in the occurrence between the groups. The independent predictors for the DOCEs or MACCEs included age, anemia, or left ventricular ejection fraction <40%. In conclusion, in older patients, S-EES implantation demonstrated favorable device-related outcomes, regardless of procedural complexity or co-morbidities. However, it requires careful attention because older patients with HIR are associated with worse clinical outcomes.<br />Competing Interests: Declaration of Competing Interest Dr. B.K. Kim reports financial support was provided by Boston Scientific Corporation. The remaining authors have no competing interests to declare.<br /> (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Humans
Sirolimus pharmacology
Prospective Studies
Stroke Volume
Treatment Outcome
Risk Factors
Ventricular Function, Left
Stents adverse effects
Registries
Prosthesis Design
Drug-Eluting Stents adverse effects
Myocardial Infarction etiology
Percutaneous Coronary Intervention adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1913
- Volume :
- 204
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 37536204
- Full Text :
- https://doi.org/10.1016/j.amjcard.2023.07.094