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The effects of the alpha-glucosidase inhibitor BAY g 5421 (Acarbose) on postprandial blood glucose, serum insulin, and triglyceride levels: dose-time-response relationships in man.
- Source :
-
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie [Res Exp Med (Berl)] 1979 Apr 23; Vol. 175 (1), pp. 87-94. - Publication Year :
- 1979
-
Abstract
- In a double-blind quadruple cross-over study the effect of a new alpha-glucosidase inhibitor (BAY g 5421) on postprandial blood glucose, serum insulin, and serum triglyceride increases was tested in 24 male healthy volunteers. They received before a standardized breakfast 50, 100, or 200 mg of BAY g 5421 or a placebo per os. The dose-time-response relationships were calculated and the drug tolerance was assessed. There was a statistically significant inhibition of the postprandial increases of the blood glucose, serum insulin, and triglyceride values. Further analysis showed no dose-dependent effect of the drug on the blood glucose values, whereas the serum insulin and triglyceride values were affected in a dose-dependent fashion. The maximal inhibitory effect on the serum insulin levels occurred 69 min after breakfast and on the serum triglyceride levels 104 min after breakfast. One hundred and 200 mg of BAY g 5421 were equally inhibitory-effective on the serum insulin levels, whereas the highest dose used was markedly more effective on serum triglyceride values than lower doses. Based on these results, a dosage of 100--200 mg of BAY g 5421/meal is recommended for clinical trials in metabolic diseases.
- Subjects :
- Administration, Oral
Adult
Clinical Trials as Topic
Diet
Dose-Response Relationship, Drug
Double-Blind Method
Humans
Male
Trisaccharides pharmacology
Blood Glucose metabolism
Glucosidases antagonists & inhibitors
Glycoside Hydrolase Inhibitors
Insulin blood
Oligosaccharides administration & dosage
Triglycerides blood
Trisaccharides administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0300-9130
- Volume :
- 175
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
- Publication Type :
- Academic Journal
- Accession number :
- 375343
- Full Text :
- https://doi.org/10.1007/BF01851237