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Effectiveness of Weekly Teriparatide Injection in Postmenopausal Patients with Hip Fractures.
- Source :
-
Clinics in orthopedic surgery [Clin Orthop Surg] 2023 Aug; Vol. 15 (4), pp. 552-559. Date of Electronic Publication: 2023 Feb 27. - Publication Year :
- 2023
-
Abstract
- Background: Teriparatide is an effective anabolic agent used in the treatment of severe osteoporosis. In addition, it is also used to promote fracture healing. The purpose of this double-blind randomized controlled trial was to evaluate the influence of weekly teriparatide administration on bone formation in hip fracture patients.<br />Methods: The control group (n = 41) was composed of patients treated with normal saline other than teriparatide, and the teriparatide group (n = 51) consisted of patients who received weekly teriparatide. Bone turnover markers, C-terminal telopeptide (CTx) and osteocalcin (OC), were assessed through blood tests at the initial hospital visit and 3-month, 6-month, and 1-year follow-ups. Dual-energy X-ray absorptiometry was performed 5 days postoperatively and at 1-year postoperative follow-up. The degree of fracture union was evaluated by comparing the radiographic union scoring system for hips using Radiographic Union Score for Hip (RUSH) scores between the two groups at 3 months, 6 months, and 1 year after surgery.<br />Results: Evaluation of the rate of change in bone mineral density over 1 year showed that the lumber bone mineral density increased by more than 7% in the experimental group. The control group did not show a difference between the CTx and OC at 6 months, but the difference between the CTx and OC values was large at 6 months in the experimental group. The mean RUSH score was significantly different between the control group and the experimental group: 12.105 and 15.476, respectively ( p = 0.004), at 3 months and 18.571 and 22.389, respectively, at 6 months ( p = 0.006).<br />Conclusions: Weekly use of teriparatide improved fracture healing, bone formation, and clinical outcomes at 1 year after hip fracture surgery by the anabolic window effect.<br />Competing Interests: CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.<br /> (Copyright © 2023 by The Korean Orthopaedic Association.)
Details
- Language :
- English
- ISSN :
- 2005-4408
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinics in orthopedic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 37529188
- Full Text :
- https://doi.org/10.4055/cios22280