Back to Search
Start Over
Synthesis and characterization of TiO 2 nanoparticles combined with geraniol and their synergistic antibacterial activity.
- Source :
-
BMC microbiology [BMC Microbiol] 2023 Aug 02; Vol. 23 (1), pp. 207. Date of Electronic Publication: 2023 Aug 02. - Publication Year :
- 2023
-
Abstract
- Background: The emergence of antibiotic resistance in pathogenic bacteria has become a global threat, encouraging the adoption of efficient and effective alternatives to conventional antibiotics and promoting their use as replacements. Titanium dioxide nanoparticles (TiO <subscript>2</subscript> NPs) have been reported to exhibit antibacterial properties. In this study, we synthesized and characterized TiO <subscript>2</subscript> NPs in anatase and rutile forms with surface modification by geraniol (GER).<br />Results: The crystallinity and morphology of modified TiO <subscript>2</subscript> NPs were analyzed by UV/Vis spectrophotometry, X-ray powder diffraction (XRD), and scanning electron microscopy (SEM) with elemental mapping (EDS). The antimicrobial activity of TiO <subscript>2</subscript> NPs with geraniol was assessed against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Escherichia coli. The minimum inhibitory concentration (MIC) values of modified NPs ranged from 0.25 to 1.0 mg/ml against all bacterial strains, and the live dead assay and fractional inhibitory concentration (FIC) supported the antibacterial properties of TiO <subscript>2</subscript> NPs with GER. Moreover, TiO <subscript>2</subscript> NPs with GER also showed a significant decrease in the biofilm thickness of MRSA.<br />Conclusions: Our results suggest that TiO <subscript>2</subscript> NPs with GER offer a promising alternative to antibiotics, particularly for controlling antibiotic-resistant strains. The surface modification of TiO <subscript>2</subscript> NPs by geraniol resulted in enhanced antibacterial properties against multiple bacterial strains, including antibiotic-resistant MRSA. The potential applications of modified TiO <subscript>2</subscript> NPs in the biomedical and environmental fields warrant further investigation.<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1471-2180
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 37528354
- Full Text :
- https://doi.org/10.1186/s12866-023-02955-1