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G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice.
- Source :
-
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2023 Aug 31; Vol. 137 (16), pp. 1249-1263. - Publication Year :
- 2023
-
Abstract
- Background: An unbalance in the renin-angiotensin (Ang) system (RAS) between the Ang II/AT1 and Ang-(1-7)/Mas axis appears to be involved in preeclampsia (PE), in which a reduction in Ang-(1-7) was observed. Here, we tested whether the reduction in the activity of the Ang-(1-7)/Mas axis could be a contributing factor for the development of PE, using Mas-deficient (Mas-/-) mice.<br />Methods and Results: Cardiovascular parameters were evaluated by telemetry before, during pregnancy and 4 days postpartum in 20-week-old Mas-/- and wild-type (WT) female mice. Mas-/- mice presented reduced arterial blood pressure (BP) at baseline (91.3 ± 0.8 in Mas-/- vs. 94.0 ± 0.9 mmHg in WT, Diastolic, P<0.05). However, after the 13th day of gestation, BP in Mas-/- mice started to increase, time-dependently, and at day 19 of pregnancy, these animals presented a higher BP in comparison with WT group (90.5 ± 0.7 in Mas-/- vs. 80.3 ± 3.5 mmHg in WT, Diastolic D19, P<0.0001). Moreover, pregnant Mas-/- mice presented fetal growth restriction, increase in urinary protein excretion as compared with nonpregnant Mas-/-, oliguria, increase in cytokines, endothelial dysfunction and reduced ACE, AT1R, ACE2, ET-1A, and eNOS placental mRNA, similar to some of the clinical manifestations found in the development of PE.<br />Conclusions: These results show that Mas-deletion produces a PE-like state in FVB/N mice.<br /> (© 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.)
- Subjects :
- Pregnancy
Female
Mice
Animals
Humans
Proto-Oncogene Proteins genetics
Proto-Oncogene Proteins metabolism
Proto-Oncogene Mas
Placenta metabolism
Renin-Angiotensin System
Receptors, G-Protein-Coupled genetics
Receptors, G-Protein-Coupled metabolism
Angiotensin II metabolism
Phenotype
Angiotensin I metabolism
Peptide Fragments metabolism
Peptidyl-Dipeptidase A metabolism
Pre-Eclampsia genetics
Pre-Eclampsia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1470-8736
- Volume :
- 137
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Clinical science (London, England : 1979)
- Publication Type :
- Academic Journal
- Accession number :
- 37527493
- Full Text :
- https://doi.org/10.1042/CS20220819