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Sphingolipid metabolism and complement signaling in cancer progression.
- Source :
-
Trends in cancer [Trends Cancer] 2023 Oct; Vol. 9 (10), pp. 782-787. Date of Electronic Publication: 2023 Jul 26. - Publication Year :
- 2023
-
Abstract
- Cancer treatment options are limited due to therapeutic resistance; thus, understanding the tumor microenvironment (TME) is crucial. Sphingolipid metabolism and complement activation products have essential roles in promoting tumor survival. Emerging evidence shows that sphingolipid signaling can regulate intracellular complement activation to induce inflammasome-mediated metastasis, offering a promising strategy for cancer therapy.<br />Competing Interests: Declaration of interests The authors declare no conflict of interest.<br /> (Copyright © 2023 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 2405-8025
- Volume :
- 9
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 37507302
- Full Text :
- https://doi.org/10.1016/j.trecan.2023.07.001