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Meta-DNA Strand Displacement for Sub-Micron-Scale Autonomous Reconfiguration.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2023 Aug 02; Vol. 145 (30), pp. 16812-16820. Date of Electronic Publication: 2023 Jul 25. - Publication Year :
- 2023
-
Abstract
- Dynamic molecular interactions in chemical reaction networks lead to complex behaviors in living systems. Whereas recent advances in programming DNA molecular reactions have reached a high level of complexity at molecular and nanometer scales, achieving programmable autonomous behavior at submicron or even larger scales remains challenging. Here, we present a mechanism of meta-DNA strand displacement reactions (M-SDRs) that is mediated solely by meta-toehold (M-toehold) using versatile submicron building blocks of meta-DNA (M-DNA). M-SDR emulates the toehold binding and branch migration processes of conventional strand displacement. Importantly, the kinetics of M-SDR can be modulated over a range of five orders of magnitude reaching a maximum rate of about 1.62 × 10 <superscript>5</superscript> M <superscript>-1</superscript> s <superscript>-1</superscript> . Further, we demonstrate the use of M-SDR to program autonomous reconfiguration in information transmission and logical computation systems. We envision that M-SDR serves as a versatile mechanism for emulating autonomous behavior approaching the cellular level.
- Subjects :
- Kinetics
DNA chemistry
Logic
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 145
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 37489598
- Full Text :
- https://doi.org/10.1021/jacs.3c04884