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Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms.
- Source :
-
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Jan; Vol. 49 (1), pp. 41-50. Date of Electronic Publication: 2023 Jul 24. - Publication Year :
- 2024
-
Abstract
- Ketamine is an open channel blocker of ionotropic glutamatergic N-Methyl-D-Aspartate (NMDA) receptors. The discovery of its rapid antidepressant effects in patients with depression and treatment-resistant depression fostered novel effective treatments for mood disorders. This discovery not only provided new insight into the neurobiology of mood disorders but also uncovered fundamental synaptic plasticity mechanisms that underlie its treatment. In this review, we discuss key clinical aspects of ketamine's effect as a rapidly acting antidepressant, synaptic and circuit mechanisms underlying its action, as well as how these novel perspectives in clinical practice and synapse biology form a road map for future studies aimed at more effective treatments for neuropsychiatric disorders.<br /> (© 2023. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1740-634X
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 37488280
- Full Text :
- https://doi.org/10.1038/s41386-023-01629-w