Molecular Imaging in Recurrent Prostate Cancer Presented as a Mixed Small Neuroendocrine Tumor/Acinar Adenocarcinoma.

Molecular imaging is an important tool for evaluating patients with prostate cancer, including those with hybrid histopathology. Although rare, mixed small neuroendocrine tumor/acinar adenocarcinoma exhibit aggressive behavior that necessitates optimal therapy. Molecular imaging has been implemented previously to assess radioligand therapy eligibility in such cases. Interestingly, the uptake of radiotracers targeting prostate-specific membrane antigen (PSMA) and somatostatin receptor may be reduced and can potentially lead to false negative readings in certain tumor types with hybrid features. Therefore, physicians should be aware of different kinds of disparities when assessing these tumor types with the aforementioned modalities.
Competing Interests: Conflict of InterestAkram Al-Ibraheem, Dhuha Ali Al-Adhami, Ahmed Saad Abdlkadir, Nabeela Al-Hajaj, Rami Ghanem, Ramiz Abu-Hijlih, and Samer Salah declare that they have no conflict of interest.
(© The Author(s), under exclusive licence to Korean Society of Nuclear Medicine 2023.)