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Inability of chlorophenols to induce 6-thioguanine-resistant mutants in V79 Chinese hamster cells.

Authors :
Jansson K
Jansson V
Source :
Mutation research [Mutat Res] 1986 Aug-Sep; Vol. 171 (2-3), pp. 165-8.
Publication Year :
1986

Abstract

The induction of mutation at the hypoxanthine-guanine phosphoribosyl transferase locus and cytotoxicities of 6 different chlorophenols (2,4- and 2,6-dichlorophenol, 2,4,5- and 2,4,6-trichlorophenol, 2,3,4,6-tetrachlorophenol and pentachlorophenol) were examined in V79 Chinese hamster cells without exogenous metabolic activation. The chlorophenols were cytotoxic to V79 cells, but failed to produce significant increases in the frequency of 6-thioguanine-resistant mutants.

Details

Language :
English
ISSN :
0027-5107
Volume :
171
Issue :
2-3
Database :
MEDLINE
Journal :
Mutation research
Publication Type :
Academic Journal
Accession number :
3748065
Full Text :
https://doi.org/10.1016/0165-1218(86)90050-9